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本文观察了IL－1对正常和输精管结扎大鼠睾丸间质细胞（Leydigcells，莱迪希细胞）细胞功能的影响。结果表明：在人绒毛膜促性腺激素（humanchoriornicgonadotropin，hCG）的作用下，正常和输精管结扎大鼠睾丸Leydig细胞培养上清中睾酮和cAMP的含量均明显高于相应对照孔，且两组比较无明显差异，说明输精管结扎后睾丸Leydig细胞对垂体激素的反应性并无改变；两组细胞受IL－1单独作用时，也表现为促进睾酮分泌；但当将IL－1和hCG一起与睾丸Leydig细胞作用时，睾酮的分泌量明显低于hCG的单独作用，两组变化相似，显示了IL－1对hCG诱导的Leydig细胞睾酮分泌的抑制作用。因此，减少睾丸局部IL－1的产生，对于预防睾酮水平的下降，具有重要意义。
In this paper, the effects of IL-1 on the function of Leydig cells in normal and vasectomized rats were observed. The results showed that the content of testosterone and cAMP in the culture supernatant of Leydig cells of normal and vasectomized rats were significantly higher than that of the corresponding control wells under the action of human chorionic gonadotropin (hCG) Significantly different, indicating that the vas deferens after testicular Leydig cells did not change the response to pituitary hormone; two groups of cells by the role of IL-1 alone also showed to promote testosterone secretion; but when the IL-1 and hCG and testicular Leydig The amount of testosterone secreted by cells was significantly lower than that of hCG alone. The changes of two groups were similar. It showed that IL-1 inhibited the testosterone secretion of hCG-induced Leydig cells. Therefore, to reduce the testicular local IL-1 production, for the prevention of the decline of testosterone, is of great significance.