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目的:评价舒血宁与前列地尔联用对糖尿病患者周围血管病变的临床疗效。方法:选取2015年1月—2016年6月间收治的糖尿病周围血管病变患者122例,采用随机分组法将其分为对照组和观察组,每组61例;对照组患者给予临床常规治疗,观察组患者在对照组基础上加用舒血宁与前列地尔注射液联用治疗,比评两组患者治疗后的总有效率以及不良反应的发生率。结果:两组患者经不同方法治疗后,股动脉、腘动脉和足背动脉的血流速度、管径均得到显著的改善(P<0.05);观察组患者的改善程度显著高于对照组(P<0.05);两组患者治疗后血糖值和Hb A1c水平均显著低于治疗前(P<0.05),但观察组的变化更加显著(P<0.05);不同方法治疗后,观察组治疗的总有效率为93.44%显著高于对照组为70.49%(P<0.05)。结论:采用舒血宁注射液与前列地尔注射液联用于治疗糖尿病患者,其周围血管病变的临床效果较为显著。
Objective: To evaluate the clinical effect of Shuxuening combined with alprostadil on peripheral vascular diseases in diabetic patients. Methods: One hundred and twenty-two patients with diabetic peripheral vascular disease who were admitted between January 2015 and June 2016 were selected and randomly divided into control group and observation group, with 61 cases in each group. Patients in control group were given routine clinical treatment, Patients in the observation group were treated with Shuxuening and alprostadil injection on the basis of the control group, and the total effective rate and the incidence of adverse reactions after treatment were compared between the two groups. Results: The blood flow velocity and diameter of the femoral artery, popliteal artery and dorsalis pedis artery were significantly improved in both groups (P <0.05) after treatment by different methods. The improvement degree of the observation group was significantly higher than that of the control group P <0.05). After treatment, the blood glucose and Hb A1c levels in both groups were significantly lower than those before treatment (P <0.05), but the changes in the observation group were more significant (P <0.05). After treatment by different methods, The total effective rate was 93.44%, which was significantly higher than that of the control group (70.49%, P <0.05). Conclusion: Shuxuening injection and alprostadil injection for the treatment of diabetic patients, the clinical effect of peripheral vascular lesions is more significant.