在母体外周血循环中，胎儿有核红细胞是最理想的研究指标，其相应的单克隆抗体中，以血型糖蛋白Ａ（ｇｌｙｃｏｐｈｏｒｉｎＡ，ＧＰＡ）特异性最强。目前常用的分选胎儿细胞方法有流式细胞技术、磁性分离法、抗体结合柱法、显微操作分离法、细胞培养等，前两者已广泛使用。通过多聚酶链反应，荧光原位杂交技术可将所得胎儿细胞进行性别预测及染色体异常的产前诊断 In the maternal peripheral blood circulation, fetal nucleated erythrocytes is the best research index, the corresponding monoclonal antibodies, the most specific glycophorin A (GPA). Currently used methods of sorting fetal cells are flow cytometry, magnetic separation, antibody binding column method, micromanipulation separation, cell culture, the first two have been widely used. Through the polymerase chain reaction, fluorescence in situ hybridization of fetal cells can be obtained for gender prediction and prenatal diagnosis of chromosomal abnormalities