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目的:探讨消瘀康胶囊对外伤性颅内血肿、硬膜外血肿、脑出血吸收期的治疗效果。方法:选择外伤性颅内血肿、硬膜外血肿、脑出血吸收期的患者,服用消瘀康胶囊,一日三次,每次三粒,疗程一个月,观察患者的脑卒中功能障碍的评估(SIAS)[1]、简易精神状态检查量表(MMSE)[2]、氧自由基代谢指标、超氧化物歧化酶(SOD)、丙二醛(MDA)、血液流变学指标氧自由基代谢等指标。结果:治疗后SIAS、MMSE明显改善、清除氧自由基的SOD、谷胱甘肽过氧化物酶(GSH-PX)明显升高(P<0.01),而反映体内过氧化反应代谢产物的MDA显著降低(P<0.01),血流变学[3]的观察在全血黏度血球压积及血沉指标等方面有明显好转。结论:消瘀康胶囊能够有效地清除体内过氧化脂质代谢产物和调节体内氧自由基代谢平衡的作用,对患者的外伤性颅内血肿、脑出血、硬膜外血肿吸收期各项指标具有明显的调节和改善作用。
Objective: To investigate the therapeutic effect of Xiaoyu Kang capsule on traumatic intracranial hematoma, epidural hematoma and cerebral hemorrhage absorption period. Methods: Patients with traumatic intracranial hematoma, epidural hematoma and cerebral hemorrhage absorption period were given Xiaoyukang capsule three times a day for three months for one month to observe the assessment of stroke dysfunction SIAS 1, MMSE 2, metabolic indices of oxygen free radicals, superoxide dismutase (SOD), malondialdehyde (MDA), indexes of hemorheology, oxygen free radical metabolism And other indicators. Results: After treatment, the SIAS and MMSE were significantly improved and the activities of SOD and GSH-PX in scavenging oxygen free radicals were significantly increased (P <0.01), while the contents of MDA in peroxidation metabolites (P <0.01), hemorrheology [3] observed in the whole blood viscosity hematocrit and ESR indicators have improved significantly. Conclusion: Xiaoyu Capsule can effectively remove lipid peroxidation products in the body and regulate the metabolism of oxygen free radicals in vivo, the traumatic intracranial hematoma, intracerebral hemorrhage, epidural hematoma absorption of the indicators have Significant adjustment and improvement.