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本文旨在研究一种能改善心脏缺血的细胞因子——转化生长因子β1(TGF—β1)对血栓栓塞性卒中家兔模型的作用。组织缺血与炎症相似,具有中性白细胞早期到达受伤部位的特点。对心、脑和其他器官的研究表明,白细胞早期到达缺血部位可能使损伤加重。在一些动物模型中,降低中性白细胞功能或活性可使缺血的大脑损伤减轻。TGF-β1在心肌缺血的模型中提供了心脏保护和其抑制白细胞和星形细胞功能的能力,提示在急性脑缺血中,这种肽具有潜在的有益作用。取新西兰怀特兔(2.5~3.2kg,雌雄皆用)21只,分为3组,每组7只,经右颈内动脉颅内输入自体血块栓子,在自体血块栓塞形成前,各组立即接受媒介对照剂(白蛋白)或者 TGF-β1(10/μg 或
This study aimed to investigate the effect of TGF-β1, a cytokine that improves cardiac ischemia, on a rabbit model of thromboembolism. Tissue ischemia and inflammation are similar, with neutrophil early arrival characteristics of the injured area. Studies of the heart, brain, and other organs have shown that early passage of leukocytes into the ischemic area may aggravate the injury. In some animal models, reducing neutrophil function or activity can reduce ischemic brain damage. TGF-β1 provides cardioprotection and its ability to inhibit leukocyte and astrocyte functions in a model of myocardial ischemia, suggesting that this peptide has a potentially beneficial effect in acute cerebral ischemia. Twenty-one New Zealand White rabbits (2.5-3.2 kg, both male and female) were divided into 3 groups with 7 animals in each group. The animals were injected intracranially with autologous clot embolus through the right internal carotid artery. Vehicle control (albumin) or TGF-β1 (10 / μg or