顺铂主要用于治疗睾丸与卵巢癌,最近还用于头颈部鳞癌,已知其有耳毒作用,早期有耳鸣耳闷症状,但往往不为病人所重视,直到晚期出现严重耳聋时始为发觉,与氨基甙类相同,顺铂的耳毒作用取决于总剂量、年龄和肾功能等因素,在治疗前有内耳功能损害者,引超前 Cisplatin is mainly used for the treatment of testicular and ovarian cancer, recently also used for head and neck squamous cell carcinoma, known to have ototoxicity, early tinnitus ear stuffy symptoms, but often not the patient’s attention until the late severe deafness Initially found that, like aminoglycosides, cisplatin ototoxicity depends on the total dose, age and renal function and other factors, prior to the treatment of inner ear damage, cited lead