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肺癌是目前全球范围内死亡率最高的恶性肿瘤[1],根据病理学分型,确诊的肺癌中约有80%为非小细胞肺癌,在美国每年新诊断的NSCLC中,有75%的患者已不能进行手术治疗[2],化疗及放疗是针对这部分患者的主要治疗方法。但是肿瘤细胞对化疗药物的耐药性往往导致治疗的失败。现就肿瘤细
Lung cancer is the most commonly diagnosed malignancy in the world [1]. About 80% of lung cancers diagnosed according to the pathological type are non-small cell lung cancer. Of the newly diagnosed NSCLC in the United States, 75% Can not be operated on [2], chemotherapy and radiotherapy are the main treatment for this part of the patients. However, the resistance of tumor cells to chemotherapeutic drugs often leads to the failure of treatment. Fine tumor now