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【目的】为探讨内皮素（ＥＴ－１）、前列环素（ＰＧＩ２）、血栓素（ＴＸＡ２）在妊娠高血压综合征（妊高征）发病中的作用。【方法】应用放射免疫法测定５５例妊高征患者，２３例正常妊娠妇女血浆ＥＴ－１，ＰＧＩ２，ＴＸＡ２浓度。【结果】①妊高征患者血浆ＥＴ－１浓度高于正常妊娠妇女，且随病情加重而上升。②中、重度妊高征患者血浆ＰＧＩ２较正常妊娠妇女低，中、重度妊高征患者血浆ＴＸＡ２较正常妊娠妇女高，两者随妊高征病情加重而下降或上升。③中、重度妊高征患者血浆ＥＴ－１与ＰＧＩ２呈负相关，与ＴＸＡ２呈正相关，ＰＧＩ２与ＴＸＡ２呈负相关。【结论】①ＥＴ－１，ＰＧＩ２，ＴＸＡ２可作为判断妊高征病情的指标。②ＥＴ－１可能是妊高征发病的主要原因。③ＰＧＩ２对ＥＴ－１具有拮抗作用，推测补充外源性ＰＧＩ２可能成为治疗妊高征的有效途径。
【Objective】 To investigate the role of endothelin (ET-1), prostacyclin (PGI2) and TXA2 in the pathogenesis of pregnancy induced hypertension (PIH). 【Methods】 Plasma ET-1, PGI2 and TXA2 levels in 55 PIH patients and 23 normal pregnant women were determined by radioimmunoassay. 【Results】 ① The plasma ET-1 level in patients with PIH was higher than that in normal pregnant women and increased with the exacerbations. ② In patients with moderate and severe PIH plasma PGI2 is lower than that in normal pregnant women. The plasma levels of TXA2 in patients with moderate and severe PIH are higher than those in normal pregnant women, both of which decrease or increase with the increase of PIH. ③ In patients with moderate and severe PIH, plasma ET-1 was negatively correlated with PGI2, positively correlated with TXA2, and negatively with PGI2. 【Conclusion】 ①ET-1, PGI2, TXA2 can be used as indicators to determine the status of PIH. ② ET-1 may be the main cause of PIH. ③ PGI2 has an antagonistic effect on ET-1, presumably exogenous PGI2 may be an effective way to treat PIH.