用间接免疫荧光法及单相琼脂免疫扩散法检测了９４例单纯性肾病患儿外周血Ｔ细胞亚群与５０例患儿的免疫球蛋白，并与正常儿童对照。结果表明，单纯性肾病患儿ＣＤ３、ＣＤ４／ＣＤ８比值及ＩｇＧ显著低于正常儿童，而ＣＤ８及ＩｇＭ显著高于正常儿童。提示Ｔ细胞亚群及免疫球蛋白失调在单纯性肾病发病机制中起重要作用。 Indirect immunofluorescence and single-phase agar immunodiffusion were used to detect the immunoglobulin in peripheral blood T cell subsets of 94 children with simple nephrotic syndrome and 50 cases of children with normal controls. The results showed that children with simple renal disease CD3, CD4 / CD8 ratio and IgG was significantly lower than normal children, while CD8 and IgM was significantly higher than normal children. Tip T cell subsets and immunoglobulin imbalance in the pathogenesis of simple nephropathy plays an important role.