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本工作以改进的足底电击应激箱造成大鼠应激,用压脚法测痛,在应激后30min 内观察了54只大鼠的心理应激镇痛(SIA)现象。实验设计了可逃避与不可逃避2种刺激情境,并分别应用安定,以观察刺激的可逃避性和安定对 SIA 的影响。结果表明:足底电击导致了明显的 SIA;处于不可逃避情境中的大鼠产生了强于可逃避组的 SIA;安定对可逃避组 SIA 抑制作用显著。结果提示了对刺激情境的认知在 SIA 现象产生中的重要作用,并有助于痛觉心理学和生理心理学实验研究工作的开展和临床疼痛问题的解决。
In this work, rats were challenged with an improved foot shock box, and the pain was measured by the presser foot test. The psychological stress analgesia (SIA) phenomenon of 54 rats was observed within 30 minutes after stress. The experiment designed two kinds of stimulus scenarios that can be avoided and can not be avoided, and applied diazepam respectively to observe the stimulus avoidance and stability on SIA. The results showed that electrical shock caused a significant SIA in the plantar and that rats in an unavoidable situation produced a stronger SIA than evasable group; diazepam had a significant inhibitory effect on escapeable group SIA. The results suggest that the cognition of stimulus situation plays an important role in SIA phenomenon and contribute to the development of experimental research on pain psychology and physiology and psychology as well as the solution of clinical pain problems.