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(一) 12只正常猴子平均呼吸頻率为46次/分,心跳为227次/分,收縮壓/舒張壓为155/12s毫米汞柱,體溫为39.0℃。平均紅血球5.3百萬/立方毫米,白血球15.7千/立方毫米,其中淋巴球50.8％,嗜中性45.0％,單核球2.0％,嗜酸性1.6％及嗜鹼性0.6％。 (二) Sb-11(H_2O_3Sb-SCH_2COONa)是5價之(月弟)酸鹽。猴子靜脈每天10毫克/千克,共3週或6週,無咳嗽、噁心嘔吐及食量減少等毒性反應,且對呼吸,血壓、心電圖、體溫及血球數等也無顯著影響。 (三) 5猴各感染日本血吸蟲尾蚴300條,其中2猴不给藥作對照,3猴自感染後第43天開始治療,劑量10毫克/千克/天,療程3週,停藥4週後解剖。對照组2猴各餘存蟲81與138條;治療組8猴分別餘存蟲0,1與13條,蟲體萎縮,所以療效非常顯著。 (四) Sb-11毒性低,對猴子能產生耐藥性,療程延長至6週亦無毒性表現。所以我們建議,臨床上吐酒石短程療法禁忌的病人,可試用Sb-11。
(1) The average respiratory rate of 12 normal monkeys was 46 beats / min, the heartbeat was 227 beats / min, the systolic / diastolic blood pressure was 155/12s mmHg, and the body temperature was 39.0 ℃. Mean red blood cells 5.3 million / cubic millimeter, white blood cells 15.7 / cubic millimeter, of which lymphocytes 50.8%, neutrophilic 45.0%, mononuclear 2.0%, eosinophilic 1.6% and basophilic 0.6%. (B) Sb-11 (H_2O_3Sb-SCH_2COONa) is a 5-valent (monthly) acid salt. Monkey’s vein 10 mg / kg daily for 3 weeks or 6 weeks, no cough, nausea, vomiting and food intake and other toxic reactions, and respiratory, blood pressure, ECG, body temperature and blood cells, etc. also had no significant effect. (3) 300 monkeys infected with Schistosoma japonicum cercariae 300, of which 2 monkeys were not given as control, 3 monkeys started treatment on the 43rd day after infection, the dose was 10 mg / kg / day, the course of treatment was 3 weeks, and the drug was stopped for 4 weeks Anatomy. The control group of 2 monkeys remaining insects 81 and 138; treatment group 8 remaining leftover monkey 0, 1 and 13, parasites atrophy, so the effect is very significant. (D) Sb-11 low toxicity, can produce resistance to monkeys, treatment extended to 6 weeks without toxicity. Therefore, we suggest that patients with clinically tartar short-course therapy should try Sb-11.