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目的 了解左旋 1 8甲基炔诺酮皮埋避孕剂对妇女非特异性免疫功能的影响 ,为其免疫安全性的确定提供依据。方法 采用单向琼脂扩散法测定 C3和C4 水平 ,采用白色葡萄球菌吞噬百分率法测定中性粒细胞吞噬功能 ,NBT阳性细胞百分率法测定杀菌功能 ,肿瘤细胞花环法测定粘附肿瘤细胞功能。结果 用药早期 C4 水平高于正常对照组 ,C3水平、中性粒细胞吞噬杀菌功能及粘附肿瘤细胞能力未见明显差别。结论 左旋 1 8甲基炔诺酮皮埋避孕剂对妇女的非特异性免疫功能影响不大。
Objective To investigate the effect of levonorgestrel 18-coated contraceptives on non-specific immune function of women and to provide basis for their immunosuppression. Methods The levels of C3 and C4 were determined by one-way agar diffusion method. The phagocytosis of neutrophils was determined by phagocytosis rate of Staphylococcus aureus, the bactericidal activity was measured by percentage of NBT positive cells, and the function of tumor cell rosette was measured. Results The level of C4 in the early stage of drug treatment was higher than that of the normal control group. There was no significant difference in the level of C3, the phagocytosis and neutrophil phagocytosis and the adhesion ability of tumor cells. Conclusion Levonituron-18 contraceptives have little effect on the non-specific immune function of women.