酚妥拉明是一个老药,它是典型的肾上腺素能甲型受体阻滞荆,过去主要供理论研究和诊断用。随着对其血液动力学作用的认识加深,临床用途逐渐扩大。已用于治疗休克,但必须充分补足血容量,临床疗效的差异可能与此有关。除了外周血管阻力、心室舒张终期压及肺动脉压减低外,又发现它有加强心肌收缩力的作用,能减轻心室负担,故又可用于心肌梗死和心绞痛,本药的发展过程表明临床药理学研究有重要意义。 Phentolamine is an old drug, it is a typical adrenergic receptor blocker Jing, the past mainly for theoretical research and diagnostic purposes. With the deepening understanding of its hemodynamic effects, clinical use gradually expanded. Has been used to treat shock, but must make full blood volume, clinical differences may be related to this effect. In addition to peripheral vascular resistance, ventricular end diastolic pressure and decreased pulmonary artery pressure, but also found that it has to strengthen the role of myocardial contractility, can reduce the ventricular burden, it can be used for myocardial infarction and angina, the drug’s development process shows clinical pharmacology Research is important.