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目的 :研究活血化瘀中药对肝硬化门静脉压力胃粘膜血流 (GMBF)的影响。方法 :用胆管结扎法制作犬肝硬化门静脉高压模型 ,分别静滴丹参或当归注射液后测定用药前后肝硬化犬血流动力学及胃粘膜血流变化 ,并与钙通道阻滞剂硝苯吡啶进行对比研究。结果 :静滴丹参、当归后 ,肝硬化犬的门静脉压 (Ppv)、嵌塞肝静脉压 (WHVP)、肝静脉压力梯度 (HVPG)较用药前均显著下降 (P<0 .0 5或 P<0 .0 1) ,而 GMBF则显著提高(P<0 .0 5 ) ,对自由肝静脉压 (FHVP)、平均动脉压 (MAP)和心率 (HR)无显著影响 (P均 >0 .0 5 ) ,对正常犬血流动力学无显著影响。静滴硝苯吡啶后肝硬化犬的 Ppv、WHVP、GMBF、MAP、HR均较用药前显著降低 (P<0 .0 5或 P<0 .0 1) ,HVPG、FHVP无显著变化。结论 :丹参和当归等活血化瘀中药可降低肝硬化犬的门静脉压 ,与硝苯吡啶比较尚可改善胃粘膜血流 ,无动脉血压与心率的变化。
Objective : To study the effect of traditional Chinese medicine for promoting blood circulation and resolving phlegm on gastric mucosal blood flow (GMBF) in cirrhotic portal hypertension. METHODS: The canine cirrhosis portal hypertension model was made by bile duct ligation and the hemodynamics and gastric mucosal blood flow of cirrhosis dogs were measured before and after administration of intravenous drip Salvia miltiorrhiza or Angelica sinensis injection respectively, and with the calcium channel blocker nifedipine. Conduct comparative studies. RESULTS: After intravenous administration of Salvia Miltiorrhiza and Angelica sinensis, the portal vein pressure (Ppv), impaction hepatic vein pressure (WHVP), and hepatic venous pressure gradient (HVPG) of liver cirrhosis dogs were significantly lower than before administration (P<0.05 or P>0.05). However, GMBF significantly increased (P<0.05), and had no significant effect on free hepatic venous pressure (FHVP), mean arterial pressure (MAP), and heart rate (HR) (all P > 0). 0 5 ), no significant effect on normal dog hemodynamics. After infusion of nifedipine, the Ppv, WHVP, GMBF, MAP, and HR of the dogs with liver cirrhosis were significantly lower than before treatment (P<0.05 or P<0.01), and there was no significant change in HVPG and FHVP. Conclusion: Salvia miltiorrhiza and Chinese angelica can reduce the portal vein pressure of liver cirrhosis dogs. Compared with nifedipine, it can still improve gastric mucosal blood flow, and there is no change in arterial blood pressure and heart rate.