论文部分内容阅读
目的观察透析对非糖尿病终末期慢性肾脏病患者胰岛素抵抗(IR)的影响,分析其相关影响因素。方法选取非糖尿病终末期慢性肾脏病患者76例,检测非透析组、血液透析组、腹膜透析组患者的BMI、腰围、空腹血糖、空腹胰岛素、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、血尿酸、超敏C-反应蛋白、血肌酐、血红蛋白等指标,计算稳态模型胰岛素抵抗指数(HOMA-IR),分析终末期慢性肾脏病患者IR发生的危险因素。结果血液透析组的HOMA-IR、空腹胰岛素和血尿酸低于腹膜透析组和非透析组;非糖尿病终末期慢性肾脏病患者HOMA-IR与BMI、腰围、总胆固醇、甘油三酯、血尿酸水平呈正相关。结论血液透析能改善非糖尿病终末期肾脏病患者IR;脂质代谢紊乱和高尿酸血症是这类患者发生IR的危险因素。
Objective To investigate the effect of dialysis on insulin resistance (IR) in non-diabetic patients with end-stage chronic kidney disease and to analyze its related factors. Methods Sixty-six patients with non-diabetic patients with end-stage chronic kidney disease were enrolled in this study. BMI, waist circumference, fasting blood glucose, fasting insulin, total cholesterol, triglyceride, high density lipoprotein cholesterol, Serum uric acid, high-sensitivity C-reactive protein, serum creatinine, hemoglobin and other indicators, calculate the homeostasis model insulin resistance index (HOMA-IR), analysis of risk factors for IR in patients with end stage chronic kidney disease. Results The levels of HOMA-IR, fasting insulin and serum uric acid in hemodialysis group were lower than those in peritoneal dialysis group and non-dialysis group. HOMA-IR and BMI, waist circumference, total cholesterol, triglyceride, serum uric acid level in patients with non-diabetic end stage chronic kidney disease Was positively correlated. Conclusion Hemodialysis can improve the IR of non-diabetic patients with end-stage renal disease. The disturbance of lipid metabolism and hyperuricemia are the risk factors of IR in these patients.