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目的:观察中西医结合治疗急性脑梗死气虚血瘀证对血清超敏C-反应蛋白(hs-CRP)与神经元特异性烯醇化酶(NSE)水平、脑梗死病灶的影响。方法:选取70例急性脑梗死气虚血瘀证患者,随机分为观察组与对照组各35例。对照组予以拜阿司匹林肠溶片、阿托伐他汀钙片、脑复康片等治疗,观察组在对照组治疗基础上加用益智活血汤加减口服。2组治疗时间均为2周。观察治疗前后血清hs-CRP、NSE水平与脑梗死病灶的变化。结果:治疗2周后,2组血清hs-CRP、NSE水平均较治疗前下降(P<0.05,P<0.01),观察组2项指标的水平均低于对照组(P<0.05)。2组脑梗死病灶大小较治疗前缩小(P<0.05,P<0.01),观察组脑梗死病灶小于对照组(P<0.05)。结论:中西医结合治疗急性脑梗死气虚血瘀证能更明显缩小脑梗死病灶,并能降低血清hs-CRP、NSE水平。
Objective: To observe the effect of combining traditional Chinese and western medicine on serum hs-CRP, NSE and cerebral infarction in patients with acute cerebral infarction with deficiency of qi and blood stasis syndrome. Methods: Seventy patients with acute cerebral infarction with deficiency of qi and blood stasis were randomly divided into observation group (35 cases) and control group (35 cases). The patients in the control group were treated with aspirin enteric-coated tablets, atorvastatin calcium tablets and naofukang tablets. The observation group was treated with Yizhi Huoxue Decoction on the basis of the control group. The two groups were treated for two weeks. Changes of serum hs-CRP, NSE levels and cerebral infarction were observed before and after treatment. Results: After 2 weeks of treatment, the serum hs-CRP and NSE levels in both groups were significantly lower than those before treatment (P <0.05, P <0.01). The two indexes in the observation group were lower than those in the control group (P <0.05). The size of cerebral infarction in 2 groups was smaller than that before treatment (P <0.05, P <0.01). The infarction size in the observation group was smaller than that of the control group (P <0.05). Conclusion: Integrative Chinese medicine treatment of acute cerebral infarction qi deficiency and blood stasis can significantly reduce the infarction lesions, and can reduce serum hs-CRP, NSE levels.