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目的探讨uPA、V-ATP酶mRNA在肝细胞癌中的表达及其意义。方法用RT-PCR方法检测45例肝细胞癌及其癌旁组织uPA和V-ATP酶mRNA表达,以7例肝血管瘤作为对照组。结果uPA mRNA在癌组、癌旁组及对照组的阳性率分别为100%、84.4%和28.6%,3组比较差异显著(P<0.05);V-ATP酶mRNA在癌组、癌旁组及对照组的阳性率分别为100%、86.7%、57.1%,3组比较均差异显著(P<0.05);以有/无肝内静脉癌栓形成和肝外转移将癌组分为转移和无转移两组,uPA、V-ATP酶mRNA在两组的表达均有差异显著(P<0.01);而它们的表达与乙型肝炎、病理分级、血清AFP水平以及肿瘤直径无明显关系(P>0.05)。结论肝细胞癌中uPA、V-ATP酶mRNA高表达与肝癌的侵袭转移有关,有可能成为临床治疗的靶点。
Objective To investigate the expression of uPA and V-ATPase mRNA in hepatocellular carcinoma and its significance. Methods The expressions of uPA and V-ATPase mRNA in 45 cases of hepatocellular carcinoma and its adjacent tissues were detected by RT-PCR. Seven cases of hepatic hemangioma were used as the control group. Results The positive rates of uPA mRNA in cancer group, paracancer group and control group were 100%, 84.4% and 28.6%, respectively (P <0.05) And control group were 100%, 86.7% and 57.1%, respectively. There was significant difference between the three groups (P <0.05). The rates of metastasis and extrahepatic metastasis in patients with / without intrahepatic vein thrombosis and extrahepatic metastasis The expression of uPA and V-ATPase mRNA in both groups had significant difference (P <0.01), but there was no significant relationship between the expression of uPA and V-ATPase and the level of hepatitis B, pathological grade, serum AFP and tumor diameter > 0.05). Conclusion The high expression of uPA and V-ATPase in hepatocellular carcinoma is related to the invasion and metastasis of hepatocellular carcinoma, which may be the target of clinical treatment.