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本文作者将HIV-1感染早期的免疫异常与三个自身免疫和免疫缺陷鼠模型的免疫异常进行了比较,并提出宿主的免疫异常与HIV-1感染早期的T_H 功能缺陷有关。其中两个鼠模型适用于HIV-1感染晚期的研究,提示CD8~+T 细胞在防止AIDS 症状出现中具有作用。感染HIV-1后T、B 细胞的功能障碍AIDS 病人T 细胞功能损害与循环CD4~+T 细胞数下降有关。虽然T 细胞数减少是AIDS 发病机理之一,但T 细胞对某些刺激的功能缺损是与量的改变无关的。已证明1名
The authors compared the immune abnormalities in the early stages of HIV-1 infection with those in the three autoimmune and immunodeficient murine models and suggested that the host’s immune abnormalities were associated with an early deficiency of T-H function in HIV-1 infection. Two of the murine models are suitable for late HIV-1 infection, suggesting that CD8 + T cells play a role in preventing the onset of AIDS symptoms. T-cell dysfunction in T and B cell-infected AIDS patients after HIV-1 infection is associated with a decrease in the number of circulating CD4 ~ + T cells. Although the decrease in T cell number is one of the pathogenesis of AIDS, the functional impairment of T cells to certain stimuli is not related to the change of quantity. Has been certified one