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目的观察生长抑素在无法行手术治疗的恶性肠梗阻治疗中的临床疗效。方法 60例恶性肠梗阻患者,随机分为常规治疗组(对照组)28例和生长抑素组(治疗组)32例,治疗组给予常规治疗加用生长抑素(6 mg/d持续静脉泵入)3~12 d。比较两组的近期临床疗效。结果治疗组临床症状较对照组明显改善,腹痛腹胀缓解率分别为81.25%、57.14%,差异有统计学意义(P<0.05);肛门恢复排便排气比率分别为71.88%、53.57%,差异有统计学意义(P<0.05),且治疗组恢复肛门排气时间(4.5±1.5)d,明显早于对照组(6.8±2.1)d(P<0.05);治疗组胃肠引流量明显少于对照组,分别为(256±152)ml/d、(489±198)ml/d,差异有统计学意义(P<0.01);腹部平片显示肠管积气积液减少消失,治疗组(84.38%)明显优于对照组(67.86%)(P<0.05);生活质量明显改善,KPS评分分别为(58±10)分、(41±9)分,两组比较差异有统计学意义(P<0.01)。结论在常规治疗基础上联合生长抑素治疗恶性肠梗阻,能显著改善患者临床症状,提高生活质量。
Objective To observe the clinical efficacy of somatostatin in the treatment of malignant intestinal obstruction that can not be surgically treated. Methods Sixty patients with malignant intestinal obstruction were randomly divided into routine treatment group (control group) 28 cases and somatostatin group (treatment group) 32 cases. Patients in treatment group were treated with somatostatin (6 mg / d) Into) 3 ~ 12 d. Compare the two groups of recent clinical efficacy. Results The clinical symptoms in the treatment group were significantly improved compared with those in the control group. The rates of abdominal distension and abdominal pain were 81.25% and 57.14%, respectively, with significant differences (P <0.05). The rates of anal defecation exhaust were 71.88% and 53.57%, respectively (P <0.05), and the time to anus recovery in the treatment group (4.5 ± 1.5) days was significantly earlier than that in the control group (6.8 ± 2.1 days) (P <0.05). The gastrointestinal drainage in the treatment group was significantly less than that in the control group Control group were (256 ± 152) ml / d and (489 ± 198) ml / d respectively, the difference was statistically significant (P <0.01); flat plain film showed disappearance of intestine gas accumulation, the treatment group (84.38 %) Was significantly better than that of the control group (67.86%) (P <0.05), and the quality of life was significantly improved. The KPS scores were 58 ± 10 and 41 ± 9, respectively <0.01). Conclusion Combined with somatostatin on malignant intestinal obstruction based on routine treatment can significantly improve the clinical symptoms and improve the quality of life.