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目的:研究基质金属蛋白酶-2、-9(MMP-2、MMP-9)在实验组的表达及意义。方法:应用免疫组织化学SP法检测50例鼻腔鳞状细胞癌(实验组)和50例鼻腔正常组织(对照组)中MMP-2、MMP-9的表达,并分析其的表达与临床症状之间的关系。结果:①在实验组和对照组中的MMP-2阳性表达检出率分别为52%(26/50)和28%(14/50),差异有统计学意义(P<0.05);②在实验组和对照组中MMP-9阳性表达检出率分别为58%(29/50)和10%(5/50),差异有统计学意义(P<0.05)。结论:提示鼻腔鳞状细胞癌的发生、发展与MMP-2、MMP-9表达有关系。MMP-2、MMP-9在实验组的阳性表达率较高,对判断患者的预后有一定作用。
Objective: To investigate the expression and significance of MMP-2 and MMP-9 in experimental group. Methods: The expressions of MMP-2 and MMP-9 in 50 cases of nasal squamous cell carcinoma (experimental group) and 50 cases of normal nasal tissue (control group) were detected by immunohistochemical SP method. The expression and clinical symptoms Relationship between. Results: ① The positive rates of MMP-2 in the experimental group and the control group were 52% (26/50) and 28% (14/50), respectively, with statistical significance (P <0.05); The positive rates of MMP-9 in experimental group and control group were 58% (29/50) and 10% (5/50), respectively. The difference was statistically significant (P <0.05). Conclusion: It is suggested that the occurrence and development of nasal squamous cell carcinoma are related to the expression of MMP-2 and MMP-9. The positive rate of MMP-2 and MMP-9 in the experimental group was higher, which had a certain effect on judging the prognosis of the patients.