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系统性红斑狼疮(SLE)是一种自身免疫病,疾病发生与自身反应性T、B细胞出现,自身抗体形成有关,多种细胞因子参与发病。肿瘤坏死因子(TNF)超家族(TNFSF)成员众多,空间结构相似,有不同程度同源性。配体为Ⅱ型跨膜糖蛋白,能以膜结合或可溶性形式发挥作用；受体为Ⅰ型或Ⅲ型膜蛋白。受体与配体结合,启动下游信号转导,诱导细胞生长、分化和凋亡,在组织自稳、炎症的免疫调节中发挥重要作用。TNF、CD40/CD40L、Fas/FasL与SLE的关系很早就受到关注,本文把近年来与SLE相关的TNFSF中的几个细胞因子作一综述。
Systemic lupus erythematosus (SLE) is an autoimmune disease, the disease occurs with its own reactive T, B cells, the formation of autoantibodies, a variety of cytokines involved in the pathogenesis. Tumor necrosis factor (TNF) superfamily (TNFSF) is a member of many, similar in spatial structure, with varying degrees of homology. The ligand is a type II transmembrane glycoprotein that can act as a membrane-bound or soluble form; the receptor is a type I or type III membrane protein. Receptor and ligand binding, start downstream signal transduction, induce cell growth, differentiation and apoptosis, plays an important role in tissue self-regulation, inflammation, immune regulation. The relationship between TNF, CD40 / CD40L, Fas / FasL and SLE has attracted much attention for a long time. In this paper, several cytokines in TNFSF related to SLE in recent years are reviewed.