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目的：观察各种恶性肿瘤及相应良性病变中 Ｄ Ｎ Ａ 含量及倍体的变化，分析其对诊断、分级和预后判断的价值。方法：利用 Ｄ Ｉ Ｐ Ａ Ｓ２００ 生物图像处理分析系统，对常见恶性肿瘤及其良性病变共５００ 例作 Ｉ Ｃ Ｍ Ｄ Ｎ Ａ 分析研究。结果：（１） 宫颈鳞癌、卵巢常见恶性肿瘤（ 浆液性及粘液性囊腺癌） 、滤泡性淋巴瘤的 Ｄ Ｎ Ａ 含量和超二倍体率均显著高于相应起源组织或良性肿瘤；（２） 结直肠高分化腺癌与良性病变之间、各种类型甲状腺癌与正常甲状腺滤泡上皮和良性肿瘤之间的 Ｄ Ｎ Ａ 含量和倍体无显著差异；（３） 乳腺浸润性导管癌、宫颈鳞癌、结直肠腺癌的分化程度越低， Ｄ Ｎ Ａ 含量均越高，超二倍体率也越高。结论： Ｉ Ｃ Ｍ Ｄ Ｎ Ａ 检测能在定量水平分析肿瘤，可有助于良恶性肿瘤的鉴别，特别是对一些交界性肿瘤和临床疑难病例的诊断可提供有价值的参考指标， Ｄ Ｎ Ａ 含量和 Ｄ Ｎ Ａ 倍体特征与某些恶性肿瘤的分化状态有关。
Objective: To observe the changes of D N A content and ploidy in various malignant tumors and corresponding benign lesions, and to analyze their value for diagnosis, grading, and prognosis judgment. Methods: A total of 500 cases of common malignancies and benign lesions were analyzed for I C M D N A using the D I P A S 200 biological image processing and analysis system. Results: (1) D N A content and hyperdiploidy rate of cervical squamous cell carcinoma, common ovarian malignant tumors (serous and mucinous cystadenocarcinoma), and follicular lymphoma were significantly higher than those of corresponding origin tissues or benign tumors. (2) There is no significant difference in D N A content and ploidy between colorectal well-differentiated adenocarcinoma and benign lesions, between various types of thyroid cancer and normal thyroid follicular epithelium and benign tumors; (3) Breast infiltration The lower the degree of differentiation of ductal carcinoma, cervical squamous cell carcinoma, and colorectal adenocarcinoma, the higher the D N A content and the higher the rate of hyperdiploids. Conclusion: The I C M D N A detection can analyze tumors at a quantitative level and can be helpful for the identification of benign and malignant tumors. In particular, it can provide valuable reference indicators for the diagnosis of borderline tumors and clinically difficult cases. D N A content and D N A polyploidy characteristics are related to the differentiation status of certain malignancies.