论文部分内容阅读
目的了解北京市顺义区常住人口麻疹抗体水平。方法选择2012年在北京市顺义区连续居住6个月以上的11个年龄组人群作为调查对象,共243名。采用调查问卷,收集调查对象的人口学特征、麻疹患病史、含麻疹成分疫苗免疫史,并采用ELISA法检测研究对象麻疹抗体水平。结果调查对象麻疹抗体阳性率为83.13%(202/243),抗体水平中位数为939.23 IU/L。男性与女性的麻疹抗体阳性率、抗体水平以及本市人口与流动人口麻疹抗体阳性率、抗体水平差异均无统计学意义(P均>0.05);有免疫史者与无免疫史者和免疫史不详者间,麻疹抗体阳性率及抗体水平差异均有统计学意义(P均<0.05),有免疫史者抗体水平高于无免疫史者和免疫史不详者。本市和流动人口麻疹抗体阳性率均以8~11月龄最低,分别为37.50%、14.29%;均以0~7月龄、1~4岁、5~9岁、35~39岁组最高,为100%,其中15~19、20~24、25~29和30~34岁组流动人口麻疹抗体阳性率均高于本市人口,差异有统计学意义(P均<0.05)。本市和流动人口麻疹抗体水平中位数均以0~7月龄最低,分别为72.51、96.07 IU/L;最高的年龄组本市人口为8~11月龄(3 940.12 IU/L),流动人口为30~34岁组(3 661.33 IU/L),其中25~29、30~34、35~39岁组流动人口麻疹抗体水平中位数高于本市人口,差异有统计学意义(P均<0.05),1~4岁组本市人口麻疹抗体水平中位数高于流动人口,差异有统计学意义(P<0.05)。本市和流动人口共调查≤14岁儿童93名,81.72%的人曾接种过含麻疹成分疫苗,接种1、2、3剂次及以上疫苗的人群,麻疹抗体阳性率在92.61%~100%之间,差异无统计学意义(P>0.05),抗体水平中位数差异无统计学意义(P>0.05)。但本市儿童不同免疫剂次间麻疹抗体阳性率、抗体水平中位数差异有统计学意义(P均<0.05)。结论北京市顺义区常住人口中,1~9岁儿童麻疹抗体水平较高,发生大范围麻疹暴发和流行的风险较小,<1岁婴儿麻疹抗体水平有待进一步提高,应进一步探索本市15岁以上年龄组免疫策略,以降低该人群发病风险。
Objective To understand the level of measles antibody in resident population in Shunyi District of Beijing. Methods A total of 243 eleven respondents from 11 age groups who lived in Shunyi District of Beijing for more than 6 months in 2012 were selected as the survey subjects. The questionnaire was used to collect the demographic characteristics of the survey subjects, the history of measles, the immunization history of measles-containing vaccine, and the level of measles antibody in the study subjects by ELISA. Results The positive rate of measles antibody in the surveyed subjects was 83.13% (202/243), and the median antibody level was 939.23 IU / L. The positive rate of measles antibody, antibody level and the positive rate of measles antibody and the antibody level between population and floating population of both sexes in both male and female were not statistically significant (all P> 0.05); those with immunization history and those without immunization history and immunization history In the unknown, the positive rate of measles antibody and the antibody level were all significantly different (all P <0.05). The antibody level of those with immunization history was higher than those without immunization history and unknown immunization history. The positive rates of measles antibody in this Municipality and floating population were the lowest in 8 ~ 11 months, which were 37.50% and 14.29% respectively, all of which were the highest in 0 ~ 7 months old, 1 ~ 4 years old, 5 ~ 9 years old, 35 ~ 39 years old , Which was 100%. The positive rate of measles antibody in floating population aged 15-19, 20-24, 25-29 and 30-34 years old was higher than that of the city population (P <0.05). The median level of measles antibody in this Municipality and floating population was the lowest among 0-7 months, 72.51 and 96.07 IU / L, respectively. The highest age group was 8 to 11 months old (3 940.12 IU / L) The floating population was 30-34 years old (3 661.33 IU / L). The median level of measles antibody among floating population aged 25-29, 30-34 and 35-39 was higher than that of the city population (P < P <0.05). The median level of measles antibody in population aged 1 ~ 4 years was higher than that of floating population. The difference was statistically significant (P <0.05). The city and the floating population surveyed 93 children ≤14 years of age, 81.72% of the people had been vaccinated with measles vaccine, vaccination vaccines 1,2,3 and above, the positive rate of measles antibody was 92.61% to 100% There was no significant difference between the two groups (P> 0.05). There was no significant difference in antibody median (P> 0.05). However, there was a significant difference in the positive rates of measles antibody and antibody between the different immunosuppressants in the city (P all <0.05). Conclusions Among the resident population in Shunyi District of Beijing, children aged 1-9 years had a higher level of measles antibody and a lower risk of a large-scale measles outbreak and epidemic. The level of measles antibody in infants <1 year old needs to be further improved, and the 15-year- The above age group immunization strategies to reduce the risk of the population.