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目的了解肝硬变大鼠和病人肝组织中 H_1和 H_2受体的变化。方法光学放射自显影术。结果大鼠肝组织受体密度(每1000μm~2银粒计数)正常/肝硬化 H_1受体:肝细胞346±32/117±18(P<0.01);肝静脉277±18/27±5(P<0.01)。肝动脉31±7/12±3(P<0.05);门静脉25±11/16±4(P<0.05);H_2受体:肝细胞289±21/168±24(P<0.01);肝动脉235±29/154±25(P<0.05);门静脉230±28/148±18(P<0.05);肝静脉261±36/101±18(P<0.01)。病人对照组/肝硬化 H_1受体:肝细胞69±19/63±15(P>0.05);肝动脉41±7/35±5(P>0.05);门静脉39±5/34±7(P>0.05);肝静脉36±8/35±5(P>0.05)。H_2受体:肝细胞512±38/168±23(P<0.01);肝动脉175±26/56±17(P<0.01);门静脉166±18/52±15(P<0.01);肝静脉313±52/239±41(P<0.01)。结论大鼠以 H_1受体占优势,人以 H_2受体为主;肝硬化大鼠及病人肝组织的 H_1、H_2受体明显低于对照组。
Objective To investigate the changes of H 1 and H 2 receptors in liver tissues of cirrhotic rats and patients. Methods Optical autoradiography. Results Rat liver tissue receptor density (counts per 1000 μm ~ 2 silver particles) normal / cirrhosis H 1 receptors: hepatocytes 346 ± 32/117 ± 18 (P <0.01); hepatic vein 277 ± 18/27 ± 5 P <0.01). Hepatic artery was 31 ± 7/12 ± 3 (P <0.05); portal vein was 25 ± 11/16 ± 4 (P <0.05); H 2 receptor: hepatocyte was 289 ± 21/168 ± 24 235 ± 29/154 ± 25 (P <0.05); portal vein 230 ± 28/148 ± 18 (P <0.05); hepatic vein 261 ± 36/101 ± 18 (P <0.01). Patients in the control group / cirrhosis H 1 receptors: hepatocytes 69 ± 19/63 ± 15 (P> 0.05); hepatic artery 41 ± 7/35 ± 5 (P> 0.05); portal vein 39 ± 5/34 ± 7 (P > 0.05); hepatic vein 36 ± 8/35 ± 5 (P> 0.05). H 2 receptor: hepatocytes 512 ± 38/168 ± 23 (P <0.01); hepatic artery 175 ± 26/56 ± 17 (P <0.01); portal vein 166 ± 18/52 ± 15 313 ± 52/239 ± 41 (P <0.01). Conclusions H 1 receptor predominates in rats and H 2 receptors predominate in humans. H 1 and H 2 receptors in liver cirrhosis rats and patients are significantly lower than those in control group.