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目的观察低渗造影剂欧乃派克350对老年糖尿病大鼠肾功能的影响。方法建立老年糖尿病大鼠模型,观察尾静脉注射欧乃派克350(10ml/kg)后,大鼠血肌酐、尿素氮以及肾组织匀浆一氧化氮(NO)、谷胱甘肽(GSH)的含量。结果老年糖尿病大鼠血肌酐、尿素氮与正常对照组比较均升高(P<0.05),肾组织匀浆一氧化氮、谷胱甘肽与正常对照组比较均下降(P<0.01,P<0.05)。注射造影剂后,血肌酐与正常对照组比较明显升高(P<0.01),肾组织匀浆一氧化氮与糖尿病对照组比较下降(P<0.05)。结论低渗造影剂可以引起老年糖尿病大鼠肾损伤,可能与糖尿病大鼠NO合成或消耗失调,进一步激活NO信号通路有关。
Objective To observe the effect of low osmolar contrast agent Omnipaque 350 on renal function in aged diabetic rats. Methods A rat model of senile diabetes was established. Serum creatinine, blood urea nitrogen and NO, GSH in renal homogenate of rats were observed after oral administration of Ornithine 350 (10ml / kg) content. Results Serum creatinine and urea nitrogen in elderly diabetic rats were significantly higher than those in the normal control group (P <0.05), and the contents of NO and GSH in the renal tissue homogenate decreased compared with the normal control group (P <0.01, P < 0.05). Compared with normal control group, serum creatinine increased significantly (P <0.01). Compared with diabetic control group, nitric oxide in renal tissue decreased (P <0.05). CONCLUSION: Hypotonic contrast agents can cause renal damage in aged diabetic rats, which may be related to the imbalance of NO synthesis or consumption and the activation of NO signaling pathway in diabetic rats.