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目的:对比盐酸小檗碱片联合四联疗法和四联疗法根除幽门螺杆菌(Hp)方案的临床效果,为临床治疗方案的选择提供参考。方法:将160例幽门螺杆菌阳性消化性溃疡患者随机分为两组。A组:口服埃索美拉唑(20 mg)+阿莫西林(1.0 g)+枸橼酸铋钾(220 mg)+克拉霉素(0.5 g),每日2次,服用10 d。B组:口服埃索美拉唑(20 mg)+枸橼酸铋钾(220mg)+阿莫西林(1.0g)+克拉霉素(0.5g),每日2次,盐酸小檗碱片300 mg,每日3次,服用10 d。观察记录Hp根除情况及不良反应。结果:两组Hp根除率分别为81.23%和87.50%,差异有统计学意义(P<0.05)。两组不良反应率比较,差异无统计学意义(P<0.05)。结论:盐酸小檗碱片联合铋剂四联组不良反应未明显增加,根除率更高,是较理想的治疗方案。
Objective: To compare the clinical efficacy of berberine hydrochloride tablets combined with quadruple therapy and quadruple therapy in the eradication of Helicobacter pylori (Hp) regimen and to provide references for clinical treatment options. Methods: 160 cases of Helicobacter pylori-positive peptic ulcer patients were randomly divided into two groups. Group A: Oral esomeprazole (20 mg) + amoxicillin (1.0 g) + bismuth potassium citrate (220 mg) + clarithromycin (0.5 g) twice daily for 10 days. Group B: oral exposure to esomeprazole (20 mg) + bismuth potassium citrate (220 mg) + amoxicillin (1.0 g) + clarithromycin (0.5 g) twice daily, berberine hydrochloride tablets 300 mg, 3 times a day, taking 10 d. Observation and record of Hp eradication and adverse reactions. Results: The eradication rates of Hp in both groups were 81.23% and 87.50%, respectively, with significant difference (P <0.05). Adverse reactions between the two groups, the difference was not statistically significant (P <0.05). Conclusion: Berberine hydrochloride combined with bismuth quadruplex group adverse reactions did not significantly increase the eradication rate is higher, is an ideal treatment.