自Yanagisawa等人首次报告血管收缩肽内皮素(endothelin)以来,许多杂志刊登了有关它的文章。虽然人们对外源性内皮素的作用和作用机制进行了广泛研究,但仍不清楚内源性内皮素的病理生理学作用。最近Toshifumi等人建立了一种抗内皮素单克隆抗体和一种夹心式酶免疫检测法。他们应用这些探针成功地证实了内源性内皮素在心肌梗塞中起到扩张作用。上述发现的意义在于:首先,用内皮素抗体治疗减小大鼠心脏梗塞面积。左结扎冠状动脉 Since Yanagisawa et al first reported the vasoconstrictive peptide endothelin, many journals published articles about it. Although extensive research has been conducted on the role and mechanism of exogenous ET, the pathophysiological role of endothelin is still unclear. Recently Toshifumi et al. Established an anti-endothelin monoclonal antibody and a sandwich enzyme immunoassay. Using these probes, they successfully demonstrated that endogenous endothelin plays a dilating role in myocardial infarction. The significance of the above findings is: First, treatment with endothelin reduces the infarct size in rats. Left ligation of the coronary arteries