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本文阐述和比较特发性生长激素缺陷(IGHD)儿童的生长、成熟状况,以评价生长激素替代疗法的作用。 方法 挑选符合以下条件的40名患者,①诊断为IGHD患者,②没有脑肿瘤或既往中枢神经系统放疗史,③年龄在5～18岁之间,④每周给予生长激素剂量为0.3mg/kg,皮下注射,每周3～6次。将资料分成3组,非治疗组(治疗不足0.2年,平均年龄10.7岁)14例,短期治疗组13例(0.2～2.0年,平均年龄8.6岁),长期治疗组13例(2.0年以上,平均年龄7.1岁)。分别记录出生年龄,站立位身高,手腕X线片推算的骨龄,
This article describes and compares the growth and maturation status of children with idiopathic growth hormone deficiency (IGHD) to evaluate the role of growth hormone replacement therapy. Methods Forty patients with the diagnosis of IGHD, no history of brain tumor or previous history of central nervous system radiation, age between 5 and 18, and weekly dose of growth hormone 0.3 mg / kg , Subcutaneous injection, 3 to 6 times per week. The data were divided into three groups: 14 patients in the untreated group (less than 0.2 years of treatment, mean age 10.7 years), 13 patients in the short-term treatment group (0.2-2.0 years, mean age 8.6 years) and 13 patients in the long-term treatment group (2.0 years or older, Average age 7.1 years old). Respectively record the age of birth, standing height, wrist X-ray estimated bone age,