Objective: To make statistics on the distribution of ApoE gene polymorphism in the Longyan area, provide data for the statistics of regional cerebrovascular diseases, explore the significance of ApoE gene polymorphism distribution for clinical guidance, diagnosis and treatment, and provide more suggestions for clinical diagnosis and treatment of cerebrovascular diseases. Methods: 800 patients with cerebrovascular disease in the Longyan area from July 2018 to April 2021 were selected as the research object,and 800 normal healthy patients were selected as the control group. The data were further analyzed according to the collected patient information, and the patients were distinguished according to age and other basic information, the type of cerebrovascular disease, ApoE gene polymorphism and blood lipid test results. The distribution of ApoE gene polymorphism in the cerebrovascular disease population in the Longyan area was given to determine the correlation between the incidence of cerebrovascular disease and the distribution of ApoE gene polymorphism. Results:In the study group, E2/E3 genotyping was the most common 400 (50.00％), and E4/E4 genotyping 6 (0.75％) was the least common;In the control group, E2/E4 genotyping was the most common 480(60.00％), and E2/E3 genotyping accounted for the second 290 (36.25％). In the study group, E3 allele was the most common 383 (47.88％),E4 allele 121 (15.12％);in the control group, E2 allele was the most common 391 (48.88％), and E3 allele 142 (17.75％). Conclusion: According to the statistics of ApoE gene polymorphism distribution in the Longyan area and the analysis of the correlation of other cerebrovascular diseases,it is found that E2/E3 genotype may be related to cerebrovascular diseases, and E3 allele may be a susceptibility factor. Through the above analysis, the occurrence of diseases can be predicted and prevented.