需氧生物对低氧的应激与适应主要通过有关低氧反应基因（ｈｙｐｏｘｉａｒｅｓｐｏｎｓｉｖｅｇｅｎｅｓ，ＨＲＧ）转录水平的调控来实现。低氧诱导因子１（ｈｙｐｏｘｉａｉｎｄｕｃｉｂｌｅｆａｃｔｏｒ１，ＨＩＦ１）及其它元件可能参与低氧的感受及低氧信号的传导、以及对低氧的急、慢相反应。寻找利于机体低氧习服适应的基因应是今后重视的研究方向 Aerobic organisms on hypoxia stress and adaptation mainly through the regulation of hypoxiaresponsivegenes (HRG) transcriptional level to achieve. Hypoxia induced factor 1 (HIF-1) and other components may be involved in hypoxia and hypoxia signal transduction, as well as hypoxic acute and slow phase response. Looking for the body conducive to hypoxia acclimation  adapt to the gene should be the focus of research in the future