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目的:观察大黄对全身炎症反应综合征患者肠屏障功能保护作用的临床研究。方法:选取120例全身炎症反应综合征患者,随机分为A、B、C组,每组40例,A组进行常规的治疗,B组口服大黄水煎液,C组大黄水煎液口服加灌肠。均治疗5天。结果:C组症状缓解时间、肠鸣音恢复时间、首次排便时间及中医症状评分与B、A组,差异均有统计学意义(P<0.05)。治疗后血清二胺氧化酶(DAO)、血浆内毒素、D-乳酸及L/M值,C组显著低于B、A组,差异均有统计学意义(P<0.05)。结论:大黄可减轻全身炎症反应综合患者内毒素血症,有利于患者早日康复。
Objective: To observe the effect of rhubarb on intestinal barrier function in patients with systemic inflammatory response syndrome. Methods: One hundred and twenty patients with systemic inflammatory response syndrome were randomly divided into A, B and C groups, 40 cases in each group. Group A received routine treatment. Group B received oral administration of rhubarb decoction, Group C rhubarb decoction orally Enema. All treatment for 5 days. Results: There were significant differences in symptom relief time, bowel sounds recovery time, first defecation time and symptom score of Chinese medicine between group B and group A (P <0.05). After treatment, serum diamine oxidase (DAO), plasma endotoxin, D-lactate and L / M values in group C were significantly lower than those in group B and group A (all P <0.05). Conclusion: Rhubarb can reduce systemic inflammatory response in patients with endotoxemia, is conducive to the early recovery of patients.