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目的 :应用多焦视网膜电图 (m ERO)一阶kernel反应 (FOK) ,检测青光眼视功能损害 ,评价其在青光眼中的诊断价值及其与视野、视盘改变的相关性。方法 :根据 1987年全国青光眼协作组拟定的标准 ,并结合视野选择了 42只青光眼和 16只可疑青光眼共 5 8只眼 ,分为早期、中期、晚期青光眼和可疑青光眼四组 ,同时选择了 3 3只正常眼 ,检测m ERG的FOKP波、N波的振幅和峰时 ,并进行统计学处理。结果 :观察了四组青光眼与正常对照组的m ERG的FOK ,结果显示 ,1、FOK的P波振幅、N波振幅、N波峰时 ,在正常对照组与三个青光眼组间有显著性差异 (P <0 0 5 ) ,与可疑组间无显著性差异 (P >0 0 5 )。P波峰时在正常对照组与其它组间无显著性差异 (P >0 0 5 ) ,但其在鼻上、鼻下、颞下三个象限正常对照组与各期青光眼组有显著性差异 (P <0 0 5 )。 2、FOK的异常检出率 (敏感性 )分别在早、中、晚期 ,可疑青光眼组和正常对照组 ,P波振幅的敏感性分别为 73 3 % ,62 5 % ,10 0 % ,62 5 %。特异性为 72 7% ,N波振幅的敏感性分别为 66 7% ,5 6 3 % ,90 9% ,5 0 % ,特异性为 63 6%。P波峰时的敏感性分别为 73 3 % ,10 0 % ,90 9% ,43 8% ,特异性为 5 1 5 % ,N波峰时的敏感性分别为 5 3 3 % ,5 0 % ,90 9% ,43 8%
OBJECTIVE: To evaluate the diagnostic value of glaucoma in glaucoma and its correlation with visual field and optic disc changes by using m ERO first-order kernel reaction (FOK). Methods: According to the standard set by the National Glaucoma Collaborative Group in 1987 and combined with field of vision, 42 glaucoma and 16 suspicious glaucoma were selected, which were divided into four groups: early stage, middle stage, late stage glaucoma and suspicious glaucoma. At the same time, Three normal eyes, FOKP wave, N wave amplitude and peak of m ERG were detected and statistically analyzed. Results: The FOK of m ERG in four groups of glaucoma and normal control group were observed. The results showed that there was significant difference between the normal control group and the three glaucoma groups in 1, FOK P wave amplitude, N wave amplitude and N wave peak (P <0 05), no significant difference between the suspicious group (P 0 05). P wave peak in the normal control group and other groups no significant difference (P gt; 0 05), but in the nasal, nasal, inferior temporal quadrant of the normal control group and the glaucoma group had significant differences P <0 0 5). The sensitivity and specificity of FOK were 73.3%, 62.5%, 100% and 62 5 respectively in early, middle and late suspicious glaucoma group and normal control group %. The specificity was 72.7%. The sensitivities of N wave amplitudes were 66.7%, 56.3%, 90.9%, 50% and 63.6% respectively. The sensitivities of P wave peak were 73 3%, 10 0%, 90 9%, 43 8% and 5 15% respectively. The sensitivities of N wave peak were 53.3%, 50.0% and 90% respectively 9%, 43 8%