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目的:探讨补肾壮阳胶囊(WSKY)对MK801所致精神分裂症模型大鼠的认知行为影响。方法:将32只雄性SD大鼠随机分为4组:对照组(生理盐水灌胃+生理盐水腹腔注射),模型组(生理盐水灌胃+MK801腹腔注射),低剂量组[0.655g/(kg·d)WSKY灌胃+MK801腹腔注射],高剂量组[3.275g/(kg·d)WSKY灌胃+MK801腹腔注射]。WSKY预处理2周后腹腔注射MK801构建精神分裂症模型,建立模型后立即进行Morris水迷宫及旷场实验。结果:旷场实验:各组大鼠自发活动总路程无明显差异;Morris水迷宫:与对照组相比,模型组逃避潜伏时间显著延长(P<0.05),原平台象限停留时间及穿越次数显著减少(P<0.05);经WSKY干预2周的高剂量组逃避潜伏时间、原平台象限停留时间及穿越次数,与对照组比较无显著差异,与模型组及低剂量组相比均有显著差异(P<0.05)。结论:补肾壮阳胶囊能改善MK801所致谷氨酸能低下精神分裂症模型大鼠的认知行为。
Objective: To investigate the effect of Bushen Zhuangyang Capsule (WSKY) on cognitive behavior of schizophrenia model induced by MK801 in rats. Methods: Thirty-two male Sprague-Dawley rats were randomly divided into 4 groups: control group (intraperitoneal injection of saline and intraperitoneal injection of saline), model group (intraperitoneal injection of saline plus intraperitoneal injection of MK801), low dose group [0.655g / kg · d) WSKY intragastric injection + MK801 intraperitoneal injection], high dose group [3.275g / (kg · d) WSKY intragastric injection + MK801 intraperitoneal injection]. Two weeks after WSKY pretreatment, MK801 was injected intraperitoneally to construct schizophrenia model. Morris water maze and open-field test were performed immediately after establishing the model. Results: In the open-field test, there was no significant difference in the total distance of spontaneous activity in each group. Morris water maze: Compared with the control group, the escape latency of the model group was significantly prolonged (P <0.05) (P <0.05). Compared with the control group, there was no significant difference between the high-dose WSKY intervention group and the low-dose group (P <0.05). Conclusion: Bushen Zhuangyang Capsule can improve the cognition of MK801-induced schizophrenia model rats.