女,4岁。于1988年4月受冷后四肢末梢发紫半月余而住院。患儿病前1月曾有感冒史,半月前每在晨起户外活动后出现鼻尖、耳垂、下颌、指、趾部皮肤紫绀及发凉,范围逐渐扩大,经保暖后可渐恢复。以后遇冷即发,发作时局部稍麻木,无明显疼痛,无酱油色尿史。曾在当地验血,发现血入针管即 Female, 4 years old. In April 1988 after the limbs were cold and more than half a month hospitalized. Children had a history of cold in January before the disease, a half months ago in the morning after the outdoor activities appear nose tip, earlobe, jaw, finger, toe skin cyanosis and cold, gradually expanding the scope, after warming can be gradually restored. After the case of cold that is, the onset of a little numbness, no obvious pain, no soy sauce color history. Have a local blood test, that blood into the needle that is