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目的:探讨托吡酯治疗癫痫的临床疗效及不良反应。方法:选择2010年12月至2012年12月金华市浦江县人民医院收治的癫痫患者80例,随机分成两组,每组各40例,对照组给予口服苯妥英钠治疗,治疗组给予口服托吡酯治疗,服药后每1个月随访1次,随访6个月以上,观察癫痫发作的情况及服药后的不良反应。结果:对照组临床疗效总有效率为60.00%,治疗组总有效率为72.50%,两组差异有统计学意义(P<0.05);对照组不良反应发生率为37.5%,治疗组不良反应发生率为22.5%,两组差异有统计学意义(P<0.05),两组患者在治疗前后检查肝肾功能、血尿常规均无异常。结论:托吡酯治疗癫痫疗效显著,可有效控制癫痫,不良反应少,值得在临床上推广使用。
Objective: To investigate the clinical efficacy and adverse reactions of topiramate in the treatment of epilepsy. Methods: Eighty patients with epilepsy who were admitted to Pujiang County People’s Hospital of Jinhua City from December 2010 to December 2012 were randomly divided into two groups (n = 40 in each group). The control group was treated with phenytoin sodium orally and the treatment group was given topiramate , After taking every 1 month follow-up 1, followed up for 6 months or more, observe the situation of seizures and adverse reactions after taking medicine. Results: The total effective rate of the control group was 60.00%, the total effective rate of the treatment group was 72.50%, the difference between the two groups was statistically significant (P <0.05); the incidence of adverse reactions in the control group was 37.5%, adverse reactions in the treatment group Rate was 22.5%, the difference between the two groups was statistically significant (P <0.05), both groups before and after treatment to check the liver and kidney function, hematuria routine no abnormalities. Conclusion: Topiramate treatment of epilepsy significant effect, can effectively control epilepsy, fewer adverse reactions, it is worth promoting in clinical use.