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以焦脱镁叶绿酸-a甲酯(MPP-a)为起始原料,经四氧化锇氧化形成焦脱镁叶绿酸-d甲酯,将其3-位甲酰基保护后与盐酸羟胺作用得到E-环成肟;利用3-位甲酰基与氯化苄基三苯基膦的Wittig反应,完成(3E/Z,131E/Z)-3b-苯基焦脱镁叶绿酸-a甲酯131-酮肟的合成及其异构体的分离.所合成的新化合物均经UV、IR、1HNMR及元素分析证明其结构.
Pyropheophorbide-a methyl ester (MPP-a) as the starting material, the osmium tetroxide oxidation to form pyropheophorbide-d methyl ester, its 3-formyl protection and hydroxylamine hydrochloride (3E / Z, 131E / Z) -3b-phenyl-pyropheophorbide-a by Wittig reaction of 3-formyl group and benzyltriphenylphosphonium chloride Synthesis of methyl ester 131-ketoxime and separation of its isomers. The structures of the new compounds were confirmed by UV, IR, 1HNMR and elemental analysis.