肝素是治疗和预防血栓性疾病的常用药物 ,随着肝素在临床上的广泛应用 ,其所引起的不良反应亦日益引起人们的重视 ,主要包括肝素抵抗、出血、血栓形成、过敏反应、骨质疏松及脱发 ,其中最严重的并发症是肝素诱导的血小板减少症 (HIT)。1　发病机制HIT是一种药物诱导的自身免疫 Heparin is a commonly used drug for the treatment and prevention of thrombotic diseases. As heparin is widely used clinically, adverse reactions caused by heparin are also attracting more and more attention, including heparin, hemorrhage, thrombosis, allergic reaction, bone Looseness and hair loss, the most serious complication is heparin-induced thrombocytopenia (HIT). 1 pathogenesis HIT is a drug-induced autoimmunity