末梢血液中嗜酸细胞增多,见于寄生虫病和变态反应性疾患,这是人们所熟知的。但是,一群呈现嗜酸细胞增多的稀有疾患,虽经多方面研究,其病因仍未阐明。1956年,Engfeldt等叙述了一种嗜酸细胞显著增多,全身组织有嗜酸细胞浸润,表现为多系统病变的疾患,并提议称为播散性嗜酸细胞性胶原病(DECD)。随后,人们把显示嗜酸性细胞增多,伴有与此病相似全身症状的其他疾患,相继报告为嗜酸细胞性白血病、播散性内脏损害伴高度嗜酸细胞增多、肺浸润型心包炎和嗜酸细胞 It is well-known that eosinophils grow in peripheral blood and are found in parasitic and allergic disorders. However, a group of rare diseases with increased numbers of eosinophils have not yet been elucidated despite various studies. In 1956, Engfeldt et al. Described a condition characterized by a marked increase in eosinophils with systemic eosinophilic infiltrates that manifested itself as a polygenic lesion and was proposed as disseminated eosinophilic collagen disease (DECD). Subsequently, people have reported eosinophilia, accompanied by systemic symptoms similar to other diseases, have been reported as eosinophilic leukemia, disseminated visceral lesions with high degree of eosinophilia, pulmonary infiltrate pericarditis and addicted to Acid cells