在药物开发过程中,药物毒性是药物研发的重要内容之一,也是制约药物能否走向临床的关键性因素。肝脏是药物代谢的重要器官,通过肝脏代谢后,多数药物对人体的毒性被消除,但是也有一些无毒或低毒的物质通过生物转化后会变成有毒或毒性更高的物质。因此,作为生物转化过程的发生器官,肝脏就 In the process of drug development, drug toxicity is one of the important contents of drug research and development, as well as the key factor that restricts whether drugs can go to clinic. The liver is an important organ for drug metabolism. Most of the drugs are eliminated from the body through the metabolism of the liver. However, some non-toxic or low-toxic substances become toxic or toxic when they undergo biotransformation. Therefore, as the organ of the bioconversion process, the liver is