本文用~(15)N-甘氨酸作示踪,测定慢性肾功能衰竭患者应用低蛋白,高热卡饮食治疗与配合复方氨基酸治疗前后的氮平衡,蛋白质代谢紊乱的改善以及血浆氨基酸浓度变化等方面的机理。通过治疗除了临床症状改善,血尿素氮下降,血转铁蛋白提高,氨平衡提高,血浆必需氨基酸水平上升外,可见血氨基流量(Q)增加,蛋白质合成速率(S)与分解速率(C)增加。氨基酸的利用率(S/Q)增加表明治疗后有蛋白质代谢紊乱的改善。 In this paper, ~ (15) N-glycine as a tracer, determination of chronic renal failure patients with low protein, high calorie diet and combined with compound amino acids before and after treatment of nitrogen balance, protein metabolism disorders and changes in plasma concentrations of amino acids mechanism. In addition to the improvement of clinical symptoms, decreased blood urea nitrogen, elevated serum ferritin, elevated ammonia balance, and elevated plasma levels of essential amino acids, the increase in blood ammonia flow (Q), protein synthesis rate (S) increase. The increase in amino acid utilization (S / Q) indicates an improvement in the protein metabolism disorder after treatment.