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目的 观察抗抑郁剂氟西汀 (百优解 )对脑梗死后抑郁及神经功能康复的影响。方法 48例脑梗死患者 ,随机分为氟西汀治疗组 (2 8例 )和对照组 (2 0例 )。在治疗前和治疗后 4、8、周分别进行改良爱丁堡 斯堪的那维亚卒中量表 (MESSS)和汉密尔顿抑郁量表 (HAMD)评分。结果 与对照组相比 ,治疗组HAMD评分和MESSS评分的减分率均较高 (P <0 .0 5)。结论 氟西汀可改善脑梗死后抑郁程度 ,也能促进神经功能康复。
Objective To observe the effect of fluoxetine (Baiyou Jie), an antidepressant, on depression and neurological rehabilitation after cerebral infarction. Methods 48 patients with cerebral infarction were randomly divided into fluoxetine treatment group (28 cases) and control group (20 cases). The modified Edinburgh Scandinavia Stroke Scale (MESSS) and Hamilton Depression Rating Scale (HAMD) scores were assessed before treatment and at 4, 8, and week after treatment. Results Compared with the control group, the reduction rates of HAMD score and MESSS score were higher in the treatment group (P <0.05). Conclusions Fluoxetine can improve the degree of depression after cerebral infarction and also promote neurological rehabilitation.