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目的探讨干扰素α-2b治疗慢性乙型肝炎最佳剂量和疗效之间的关系。方法选择120例慢性乙肝患者,分为两组,其中3MU组60例,用α-2b干扰素300万U肌肉注射;5MU组60例采用α-2b干扰素500万U肌肉注射,疗程6个月。结果5MU组HBeAg和HBVDNA阴转率和抗-HBe阳转率均显著高于3MU组;5MU剂量组的完全应答率高于3MU剂量组;5MU剂量组病情稳定率显著高于3MU剂量组;而5MU组的无应答率则显著低于3MU组;但部分稳定率和病情反复率两组无显著差异。结论干扰素剂量与抗病毒效果有一定的关系。
Objective To investigate the relationship between the best dose of interferon α-2b in the treatment of chronic hepatitis B and its curative effect. Methods 120 patients with chronic hepatitis B were selected and divided into two groups, of which 60 cases in 3MU group were injected intramuscularly with 3 million U of α-2b interferon; 60 in 5MU group were intramuscularly injected with 5 million U α-2b interferon in 6 cases month. Results The negative rate of HBeAg and HBVDNA in 5MU group and the positive rate of anti-HBe were significantly higher than those in 3MU group. The complete response rate in 5MU group was higher than that in 3MU group. The stability of 5MU group was significantly higher than 3MU group. No response rate was significantly lower in the 5MU group than in the 3MU group; however, there was no significant difference between the two groups in partial stability and disease recurrence rate. Conclusion Interferon dose and anti-viral effect have a certain relationship.