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目的:观察电刺激大鼠岛叶皮质及皮质下中枢对心脏自主神经活性的影响。方法:将36只雄性健康大鼠随机分成6组,假手术组,岛叶周边躯体感觉皮质区组、岛叶刺激组、杏仁核组、下丘脑腹内侧核组、延髓迷走背核组,每组6只,用500μA,50Hz电流进行电刺激,通电达1h后,观察大鼠的心率、血压、心率变异性参数值。结果:①岛叶刺激组的血压、心率较假手术组和岛叶周边躯体感觉皮质区组有明显升高,差异有显著性意义(P<0.01)。②岛叶、杏仁核、丘脑下部、延髓迷走背核刺激组的心率变异参数值降低,表现为均方根值、总频、高频、低频、混沌参数值均降低,与对照组比较差异有显著性意义(P<0.01),而低频/高频升高,表明心脏副交感神经活性降低,交感神经活性增强。结论:提示在岛叶及联系心脏的神经节通路的任何部位受到病理性刺激时,必须加强心脏自主神经活性的监测,以防脑源性不良反应发生。
Objective: To observe the effects of electrical stimulation of island cortex and subcortical centralis on cardiac autonomic nervous activity in rats. Methods: Thirty-six male healthy rats were randomly divided into 6 groups: sham operation group, somatosensory cortex area around insula, insula stimulation group, amygdala group, hypothalamic ventromedial nucleus group, medullary vagal dorsal nucleus group Group 6, with 500μA, 50Hz current electrical stimulation, power for 1h after the observation of rat heart rate, blood pressure, heart rate variability parameter values. Results: ① The blood pressure and heart rate in insula intervention group were significantly higher than those in sham-operated group and peripheral somatosensory cortex group (P <0.01). (2) The parameters of heart rate variability decreased in insula, amygdala, hypothalamus and medullary vagal dorsal radicular nucleus stimulated group, showing the rms value. The total frequency, high frequency, low frequency, chaos parameters decreased, compared with the control group Significant significance (P <0.01), and low frequency / high frequency, indicating that the heart parasympathetic activity decreased sympathetic activity increased. CONCLUSIONS: It is suggested that pathological stimulation of any part of the ganglion pathway and the ganglion pathways associated with the heart should be used to monitor cardiac autonomic activity to prevent brain-derived adverse reactions.