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目的：观察全凭静脉联合喉罩七氟醚吸入麻醉在腹腔镜辅助下阴式子宫全切术中的临床疗效。方法将60例拟行子宫全切术患者随机分为观察组和对照组，观察组采用全凭静脉联合喉罩七氟醚吸入麻醉，对照组采用全凭静脉麻醉。记录两组患者麻醉诱导前（T0）、插入喉罩前（T1）、插入喉罩即刻（T2）、切皮即刻（T3）、拔除喉罩前（T4）、拔除喉罩后即刻（T5）的血流动力学指标心率（HR）、平均动脉压（MAP）。观察两组麻醉起效时间、子宫松弛度、术后苏醒时间、体动发生及麻醉效果。结果观察组血流动力学较对照组稳定（P＜0．05）。观察组麻醉起效时间和术后苏醒时间分别为（5．2±1．1）min、（12．2±4．3）min，较对照组（11．3±2．1）min、（15．4±4．9）min显著缩短（P＜0．05），子宫松弛度、体动发生及麻醉效果均显著优于对照组（P＜0．05），差异有统计学意义。结论全凭静脉联合喉罩七氟醚吸入麻醉对腹腔镜辅助下阴式子宫全切术患者的血流动力影响较小，并能增强麻醉效果且生理影响轻微，值得临床推广应用。“,”Objective To study the clinical therapeutic effects of total intravenous anesthesia combined with laryngeal mask inhalation anesthesia with sevoflurane in the course of the laparoscope-assisted total hysterectomy. Methods 60 cases of hysterectomy were divided randomly into observation group and control group. The observation group was treated by total intravenous anesthesia combined with laryngeal mask inhalation anesthesia with sevoflurane , while the control group was treated by total intravenous anesthesia only. The following data of HR and MAP were recorded and analyzed statistically , including the data of HR and MAP before anesthesia induction (T0), before laryngeal mask intubation (T1), at the moment of laryngeal mask intubation (T2), at the moment of skin incision (T3), before laryngeal mask extubation (T4), and after the moment of laryngeal mask extubation (T5). The onset time of anesthesia,the degree of uterine relaxation, postoperative recovery time, the occurrence of body movement and anesthetic effect were observed. Results Comparing the data of hemodynamics between the two groups, the observation group was more stable than the control group (P<0.05). The onset time of anesthesia and postoperative recovery time of the observation group [(5.2±1.1) min and (12.2±4.3) min] were significantly shorter than those of the control group[(11.3±2.1) min and (15.4±4.9) min] (P<0.05). Comparing the degree of uterine relaxation, the occurrence of body movement and anesthetic effect , the observation group is all superior to the control group ( P<0 . 05 ) . Conclusion There is the smaller hemodynamics influence on total hysterectomy cases by using total intravenous anesthesia combined with laryngeal mask inhalation anesthesia under laparoscope , which can enhance anesthetic effect with a mild physiological effect. It is well worth popularizing and applying clinically.