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可乐定(Clonidine)是一种α_2受体激动剂,主要抑制中枢交感神经的传出冲动而导致较强的降压作用,已广泛用于治疗各种高血压。自1962年合成以来,不仅在药理研究方面进展迅速,最近已从牛和大鼠脑内分离、提纯出一种内源性可乐定样物质,而且在临床应用方面也发现了不少的新用途。一、预防偏头痛经数百例临床应用证明,小剂量可乐定(每日50～150μg)预防偏头痛有一定效果,它可减少发作次数并改善症状,对酪胺引起的偏头痛尤为有效。Barrie等采用双盲法比较了可乐定与安慰剂对107例偏头痛患者的疗效,口服每次25～50μg,一日2次,共6周,结果59%的病人有效,而安慰剂组
Clonidine is an alpha-2 receptor agonist that suppresses the afferent urge of the central sympathetic nerve to cause a strong antihypertensive effect and has been widely used to treat various types of hypertension. Since its synthesis in 1962, it has not only made rapid progress in pharmacological research, but has recently isolated and purified an endogenous colaminate substance from the bovine and rat brain, and has also found many new uses in clinical applications . First, the prevention of migraine through hundreds of cases Clinical evidence that small doses of clonidine (50 ~ 150μg daily) prevention of migraine have a certain effect, it can reduce the frequency of attacks and improve symptoms, particularly for tyramine-induced migraine. Barrie et al compared the efficacy of clonidine and placebo in 107 migraine sufferers by a double-blind method. Orally administered 25 to 50 μg orally twice daily for 6 weeks resulted in 59% of patients being effective, whereas placebo