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Fibronectin(Fn)是分子量为235,000的 A 链和分子量为230.000的 B 链在碳原子末端附近以二硫键结合的多聚体糖蛋白,它分布在结缔组织基底膜及多数细胞表面,也存在于血中。其生理机能还不十分明了,但已明确,它与细胞粘接、组织构筑及网状内皮系统的机体防御机能有关。近年来,虽然在测量各种疾病血浆 Fn 浓度,研究其与疾病的关系,但尚无关于甲状腺机能方面的报道。作者测定了甲亢及甲低患者的血浆 Fn 浓度,发现 Fn 和甲状腺机能有密切关系,现报道如下。
Fibronectin (Fn) is an A-chain with a molecular weight of 235,000 and a B chain with a molecular weight of 230,000. It is a disulfide-bonded multimeric glycoprotein distributed around the terminal carbon atom and distributed on the surface of connective tissue basement membranes and most of the cells. Blood. Its physiological function is not very clear, but it has been clear that it is cell adhesion, tissue construction and reticuloendothelial system of the body’s defensive function. In recent years, although the measurement of plasma Fn concentrations in various diseases to study its relationship with the disease, but no reports of thyroid function. The authors measured the plasma Fn concentrations in patients with hyperthyroidism and hypothyroidism and found that Fn and thyroid function are closely related, are reported below.