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目的观察慢性颅室内给予选择性5-HT2C受体拮抗剂RS102221是否能阻止醋酸脱氧肾上腺皮质激素-盐(DOCA)高血压大鼠血压的发展,以证实中枢神经系统5-HT2C受体参与了血压的调节和高血压的病理。方法通过导管,用微型渗透泵以恒定速率脑室输注选择性5-HT2C受体拮抗剂RS102221,观察拮抗中枢神经5-HT2C受体后对醋DOCA高血压大鼠(n=6)血压的影响。此外检测了5-HT2C受体拮抗剂对DOCA大鼠主动脉等张收缩力的影响。结果脑室输注RS102221减低DOCA大鼠血压的发展。5-HT2c受体拮抗剂的治疗消除了DOCA大鼠和对照组大鼠主动脉环对5-HT的反应差异。结论中枢神经系统5-HT2C受体参与了DOCA大鼠血压的调节和高血压的病理,其主动脉5-HT受体亚型的改变可能是高血压病理之一。
Objective To investigate whether chronic intracerebroventricular administration of a selective 5-HT2C receptor antagonist, RS102221, prevents the development of blood pressure in DOCA hypertensive rats to confirm that central nervous system 5-HT2C receptors are involved in blood pressure Regulation and Hypertensive Pathology. Methods The selective 5-HT2C receptor antagonist RS102221 was infused through the ventricle at a constant rate with a micro-osmotic pump through a catheter to observe the effect of antagonizing central 5-HT2C receptor on the blood pressure of vinegar DOCA hypertensive rats (n = 6) . In addition, the effect of 5-HT2C receptor antagonist on the isokinetic aortic contractions in DOCA rats was also examined. Results Intraventricular infusion of RS102221 reduced the development of blood pressure in DOCA rats. Treatment with 5-HT2c receptor antagonists abrogated the 5-HT responses of the aortic rings in DOCA and control rats. CONCLUSIONS: Central nervous system 5-HT2C receptors are involved in the regulation of blood pressure and the pathogenesis of hypertension in DOCA rats. The change of aorta 5-HT receptor subtypes may be one of the pathogenesis of hypertension.