目的了解我市新生儿脐血铅水平及其环境影响因素。方法采用石墨炉原子吸收光谱法对新生儿脐带血及其产妇静脉血各 2 0 9份进行血铅测定 ,以面询及问卷形式对相应的 2 0 9名产妇进行了环境因素的调查 ,用多因素统计分析的方法分析对脐血铅水平有明显作用的影响因素。结果 2 0 9例脐血铅水平呈正偏态分布 ,范围在 34～ 191μg L ,几何均数为 77 3μg L ,≥ 10 0 μg L的占30 6 2 %。产妇血铅和新生儿脐血铅水平显著性相关 (r=0 74 5 ,P <0 0 1)。研究还发现孕期被动吸烟、燃料类型、孕周、居室距街道距离为胎儿期铅暴露危险因素。结论目前贵阳市新生儿脐血铅呈高水平暴露 ,主要与母亲及环境因素 ,如燃料类型、孕周、居室距街道距离等 ,应引起高度重视 Objective To understand the cord blood lead levels of newborns in our city and its environmental factors. Methods The blood lead levels of neonates with umbilical cord blood and their maternal venous blood were determined by graphite furnace atomic absorption spectrometry. The environmental factors were investigated by face-to-face interviews and questionnaires with 290 pregnant women. Multivariate statistical analysis of the factors that have a significant effect on cord blood lead levels. Results There were positive skewed distributions of lead levels in 209 cases of umbilical cord blood ranging from 34 to 191 μg L with geometric mean of 77 3 μg L and ≥ 10 0 μg L accounting for 30 6 2%. Maternal blood lead and cord blood lead levels were significantly correlated (r = 0 74 5, P 0 01). The study also found that passive smoking during pregnancy, fuel type, gestational age, distance from the street to the fetus lead exposure risk factors. Conclusion Currently, there is a high level of cord blood lead exposure in neonates in Guiyang City, which is mainly due to the relationship between mothers and environmental factors such as fuel type, gestational age, distance from residential area to the street, etc.