论文部分内容阅读
目的分析四川省自贡市2014年3例单增李斯特菌感染的临床特征及其病原学特征。方法搜集临床病例信息;采用血清分型,脉冲场凝胶电泳技术和多位点序列分型方法对单增李斯特菌进行分子分型。结果 3例患者均为免疫力低下人群,有发热和败血症症状;3株单增李斯特菌中2株为1/2a血清型、ST8型,1株为1/2b血清型、ST778型,3株PFGE带型均不同。结论免疫力低下人群易受单增李斯特菌侵袭性感染。通过与国内外食品及病人单增李斯特菌相关流行学资料比较,提示国外流行克隆群以及国内某些流行型菌株可引起国内李斯特菌病散发,甚至成为将来暴发的隐患。
Objective To analyze the clinical characteristics and etiological characteristics of 3 cases of Listeria monocytogenes infection in Zigong city of Sichuan province in 2014. Methods The clinical cases were collected. Serotyping, pulsed-field gel electrophoresis and multi-locus sequencing were used to genotype Listeria monocytogenes. Results Three patients were all immunocompromised and had fever and sepsis. Two of the three strains of Listeria monocytogenes were serotype 1/2 serotypes, ST8 serotypes, one serotype 1 / 2b serotype, ST778 type 3 Strains PFGE band type are different. Conclusions Immunocompromised people are susceptible to Listeria monocytogenes infection. Comparing the epidemiological data of Listeria monocytogenes between food and patients both at home and abroad, it is suggested that the epidemic clones in foreign countries and some endemic strains in China may cause the spread of Listeriosis in China and may even become the hidden danger in the future.