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目的 探讨鼻咽癌发病与变态反应性疾病的关系。方法 对 49例治疗前鼻咽癌和 5 6例变应性鼻炎的诸临床参数进行探讨 ,测定总IgE、特异性IgE和EB VCA /IgA皮肤过敏原及了解他们的过敏性鼻炎史 ,以 10 0名健康人为对照组。 结果 ①NPC组的总IgE量和特异性IgE阳性率明显低于变应性鼻炎组 (P <0 .0 1) ;②NPC组的过敏性鼻炎史和过敏原阳性率明显低于变应性鼻炎组 (P <0 .0 1) ;③NPC组的EB VCA/IgA滴度明显高于变应性鼻炎组 (P <0 .0 1)。 结论 变应性鼻炎组患NPC的概率很低 ,其机体的免疫状态与肿瘤的发生、发展有密切关系。
Objective To investigate the relationship between the incidence of nasopharyngeal carcinoma and allergic diseases. Methods The clinical parameters of 49 cases of pre-treatment NPC and 56 cases of allergic rhinitis were investigated. The total IgE, specific IgE and EB VCA / IgA skin allergens were detected and their history of allergic rhinitis was observed. 0 healthy people as control group. Results ① The total IgE levels and the specific IgE positive rate in NPC group were significantly lower than those in allergic rhinitis group (P <0.01). ② The history of allergic rhinitis and allergen positive rate in NPC group were significantly lower than those in allergic rhinitis group (P <0.01). The EBVA / IgA titers in NC group were significantly higher than those in allergic rhinitis group (P <0.01). Conclusion The incidence of NPC in patients with allergic rhinitis is very low, and the immune status of the body is closely related to the occurrence and development of tumors.